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Introduction of the project：
Creating polygenic risk scores can be a daunting process for people without any genetic background. To simplify this process for the ENIGMA MDD working group, which includes many neuroscientists, I have developed a user-friendly pipeline for generating polygenic scores. This project is part of an international collaboration that I am leading.
#User-friendly #Comprehensive logs for project leaders #Comprehensive quality check and data harmonisation between datasets
📝 Main steps of the pipeline
- Check genome build.
- Create genomic relationship matrix and genetic principal components.
- Determine reference panel for clumping.
- Create polygenic scores based on site-specific and across-site SNP lists.
- Generate a large number of polygenic risk scores for multiple traits using PRSice.
- Check all the files generated and report any missing files.
📕 Manual
📎 References
- ENIGMA MDD working group:
- PRSice:
Please email me if you have any questions.
- 作者:Xueyi Shen
- 链接:https://scholar.google.com/citations?user=d_VoC2MAAAAJ&hl/article/ENIGMA
- 声明:本文采用 CC BY-NC-SA 4.0 许可协议，转载请注明出处。